ABSTRACT
Objective To evaluate the clinical prevention and cure efficiency of panax notoginosides(PNS) in patients with chronic renal failure.Methods 60 patients with chronic renal failure were selected and randomly divided into the control group and the observation group,with 30 cases in each group by random number table.The patients in the control group underwent regular maintenance hemodialysis(MHD),while the patients in the observa-tion group were given PNS glucose injection on the base of the control group for two months treatment.Comparison was made between the two groups in the aspect of liver filament four items,renal function,blood lipids and the levels of TGF-β1 ,TIMP-1 expression for renal fibrosis.Results After two months treatment,the liver filament four items (t=3.94-5.62,all P<0.05),renal function (t=4.15,4.29,all P<0.05),blood lipids (t=3.83 -5.47,all P<0.05)and the level of TGF-β1,TIMP-1 were all significantly decreased in the observation group,while HA, blood lipids and the level of TGF-β1(t=5.19,P<0.01),TIMP-1(t=4.16,P<0.05)were also decreased in the control group.All the indexes of the observation group were much significant than those of the control group.Total effective rate of the observation group was 83.33%,which was significantly higher than 66.67% of the control group (χ2 =5.16,P<0.05).There was no adverse reaction in the observation group.Conclusion PNS could improve renal fibrosis by lowering the level of TGF-β1 and TIMP-1 ,and could be used as conventional auxiliary drug for patients with chronic renal failure.
ABSTRACT
Objective To observe the effect of Niaoduqing granules on chronic renal failure in patients with blood lipid and blood homocysteine.Methods Patients with chronic renal failure were divided into observation group and control group by number table method,two groups of patients were both given low salt,low fat and high quality low protein diet,controlling blood pressure and blood sugar,correcting anemia,correcting calcium and phosphorus meta-bolic disorders,correcting of acidosis,while patients with combined infection were given positive anti infection treat-ment.Observation group was treated with Niaoduqing granules on that basis.The changes of triglyceride(TG),total cholesterol( HDL-C) ,total cholesterol( CHO) ,low-density lipoprotein( LDL-C) ,and plasma homocysteine( Hcy) were observed before and after treatment in the two groups.Results After treatment,CHO,TG,HDL-C,LDL-C, Hcy in the control group were respectively (4.83 ±0.22)mmol/L,(2.21 ±0.30)mmol/L,(0.69 ±0.11)mmol/L, (4.30 ±0.32)mmol/L,(24.35 ±7.05)μmol/L,that threre was no significant changes before and after treatment.In the observation group,TG,LDL-C,Hcy were (1.38 ±0.18)mmol/L,(3.29 ±0.13)mmol/L,(14.54 ±3.56)umol/L respectively after treatment,and which were significantly lower than that before treatment ( t=1.45,2.13,4.28,all P<0.05).HDL-C (1.42 ±0.31)mmol/L,were significantly increased after treatment as compared with that before treatment (t=3.88,P<0.05).The difference of Hcy,TG,LDL-C,HDL-C and CHO after treatment was statisti-cally significantin between the two groups (t=1.34,2.08,1.10,3.88,all P<0.05).Conclusion Niaoduqing gran-ules can improve lipid metabolism disorders in patients with chronic renal failure,and can reduce the serum homocys-teine.